Thursday 21 May

 

11:30-13:00 Registration

12:00-13:00  Lunch symposium –Chiesi Pharma AB
                         Welcome and introduction – Prof. Åke Sjöholm (SE)
                         Lipodystrophy diagnosis and treatment – an overview –Prof. Baris Akinci, Izmir Biomedicine and Genome Center & DEPARK, Dokuz Eylul                                                               University Health Campus, Izmir, Turkey

                         Experience with lipodystrophy in atypical diabetes – Prof. Åke Sjöholm (SE)

13:00-13:10  Opening and welcome remarks – Åke Sjöholm (SE)

13:10-13:55   Keynote lecture: Factors affecting the progression rate from seroconversion to autoantibody positivity to clinical type 1 diabetes – Mikael Knip (FIN)
                        Chair: Daniel Espes (SE)

13:55-14:15  Coffee and visit to exhibition

14:15-15:00  Barndiabetesfondens Johnny Ludvigsson Nordic Prize: Early signs of type 1 diabetes – Riitta Lahesmaa (FIN)
                       Chair: Johnny Ludvigsson (SE)

15:00-15:30  Barndiabetesfondens Young Swedish Investigator Prize:
                        Investigations of local immune regulatory mechanisms in type 1 diabetes – Gustaf Christoffersson (SE)
                        Chair: Johnny Ludvigsson (SE)

15:30-16:30 Abstract session #1A:

                       Cord Blood Iron Status has Age-specific Role in Future Type 1 Diabetes Diagnosis – Debojyoti Das
                       Johnny Ludvigsson

                       Epigenetic–proteomic network crosstalk at birth across HLA risk groups in type 1 diabetes – Shamila Darvish Alipoor Astaneh
                       Angelica Ahrens, Julia Åkesson, Johnny Ludvigsson

                      Integrated analysis of clinical course and proteomics data in DIAGNODE-2 patients – Debojyoti Das
                      Indusmita Routray, Johnny Ludvigsson

                      Stem cell derived islet organoids attract T cells, resulting in MHC matched organoid destruction by type 1 diabetic patient T cells. – Robin Lindsay
                      Xenia Podlipensky, Kina Adjieva, Marleen Bootsma, Svitlana Vasylovska, Anja Ivis, Carl Andersson, Gustaf Chistoffersson, Joey Lau

                      Pancreatic islets in mice and humans: unravelling mechanisms driving beta cell proliferation under metabolic stress – Leonie Reible
                      Teresa Pereira, Daniel Espes

                       Chair: Signe Schmidt (DK)

 

15:30-16:30   Abstract session #1B:
                         Regulation of insulin secretion by Ras signalling in pancreatic β-cells – Yunjian Xu
                        Moa Södergren, Santiago Echeverry, Per-Eric Lund, Oleg Dyachok, Olof Idevall, Sebastian Barg, Anders Tengholm

                         Novel METTL3/14 methyltransferase activators for protecting pancreatic beta- cells in diabetes mellitus – Julia Kiva, Huini Li, Maria Lindahl

                         Increasing the enteroendocrine cells by stimulating secretory progenitors with a Vcp-mediated autophagy activator – Lorenzo Buttò
                         Lianhe Chu, Jiarui Mi, Stefan Ebmeyer, Jeremie Charbord, Agnese Kocere, Anna Johansson, Olov Andersson

                        The Welander TIA1 mutation dedifferentiates human insulin-producing cells by upregulating MYC, an effect prevented by the GLP-1R agonist                                                                 liraglutide – Tongjian Zhao, Jing Cen, Xuan Wang, Mingyu Yang, Joey Lau, Anders Tengholm, Åke Sjöholm, Nils Welsh

                        Characterization of glucose tolerance, islet cell function, and insulin sensitivity in patients with Welander distal myopathy – Åke Sjöholm
                        Zhanchun Li, Joey Lau, Sarah-Ålivia Mänd, Niklas Dahl, Per-Ola Carlsson, Nils Welsh

                        Chair: Daniel Espes (SE)

16:30-17:15   Keynote lecture: GRK-biased adrenergic agonists for the treatment of type 2 diabetes and obesity – Tore Bengtsson (SE)
                       Chair: Åke Sjöholm (SE)

17:15-18:15   Novo Nordisk Foundation Nordic Diabetes Prize – Charlotte Ling (SE)
                       Chair: Lena Eliasson (SE)

18:15-18:30  Short break

18:30-19:30  Role of VEGF-B signaling in diabetic complications: focusing on fatty liver disease and diabetic stroke – Ulf Eriksson (SE)
                        Chair: Åke Sjöholm

19:30-           Welcome Reception

Friday 22 May

 

08:00-08:45 Knud Lundbæk Award – Anna Krook (SE)
                         Chair: Elisabeth Qvigstad (NO)

08:45-09:30 Keynote lecture: Lipodystrophies and the road to diabetes – Fredrik Karpe (UK)
                        Chair: Esben Söndergaard (DK)

09:30-10:30 Abstract session #2A:

Anti-CD3 monoclonal antibody modulates gamma-aminobutyric acid (GABA)ergic activity in T cells from healthy and type 1 diabetes individuals –                                                         Zhe Jin, Bryndis Birnir, Jarl Hellman

Characterization of the human virome in a childhood Type 1 diabetes cohort; focus on circoviruses – Amanj Bajalan
                         Edmundo Grisard, Claudia Beck Eichler Jonsson, Tobias Allander, Björn Andersson, Johnny Ludvigsson

Early life islet autoimmunity in type 1 diabetes among children frequently followed in a prospective birth cohort study – Nelli Rönkä
                         Tiia Honkanen, Anni Kyrönniemi, Toni Valtanen, Johanna Lempainen, Heikki Hyöty, Jorma Toppari, Jaakko Koskenniemi, Mikael Knip, Taina Härkönen,                                   Tytti Pokka, Riitta Veijola

Gene Expression Signatures Associated with Disease Progression in Individuals with Newly Diagnosed Type 1 Diabetes: Insights from the                                                                         INNODIA Study – Tomi Suomi, Inna Starskaia, Omid Rasool, Ubaid Ullah Kalim, Sylvaine Bruggraber, Loredana Marcovecchio, Emile Hendricks,
Lut Overbergh, Mark Peakman, Timothy Tree, Søren Brunak, Anke M Schulte, Chantal Mathieu, Mikael Knip, Riitta Lahesmaa, Laura L Elo

Chair: Gustaf Christoffersson (SE)

09:30-10:30  Abstract session #2B:

Effect of impaired glycogenolysis and glycogen excess on exercise-mediated glucose metabolism in skeletal muscle: Insights from novel mouse                                                               models – Dipsikha Biswas, Marianne Agerholm, Joachim Nielsen, Mohd. Syed Ahanger, Elton Zeqiraj, Kei Sakamoto

                      Exploring predictors for long-term clinical benefit after gastric bypass and sleeve gastrectomy in type 2 diabetes: A Machine Learning Approach –                                                       Gudrun Höskuldsdóttir,  Ala Mejaddam, Moa Lugner, Hanne Carlsen, Araz Rawshani, Ingrid Larsson, Johan Ottosson, Katarina Eeg-Olofsson,
Kerstin Landin-Wilhelmsen, Björn Eliasson

Extracellular Vesicle associated Glycosylated Sphingolipid Alterations in Type 2 Diabetes Impair Adipocyte Glucose Metabolism – Daan Paget
Jutta Jalkanen, Svetlana Michurina, Kirstin MacGregor, Antonio Checa, Niklas Mejhert, Taras Sych, Erdinc Sezgin, Harriet Wallberg-Henriksson,                                                         Juleen Zierath, Anna Krook

Therapeutic Targeting of the ANGPT2/TIE2 Signaling Axis Improves Diabetic Nephropathy in the BTBR OB/OB Mouse –
                     Amanda M. Marks-Hultström
                       Marie Jeansson

Tuning GRK2-biased β₂ signaling: next-generation muscle-targeted modulators with enhanced metabolic and anabolic profiles – Nodi Dehvari
Anastasia Kalinovich, Carina Halleskog, Hamza Bukhari, Sofia Karlström, Tore Bengtsson

Chair: Helga Sigurónsdóttir (IS)

 

10:30-10:50 Coffee and visit to exhibition

10:50-11:35 Keynote lecture: Exercise timing and circadian regulation of metabolism in type 2 diabetes – Harriet Wallberg (SE)
                        Chair: TBN

11:35-12:20 Keynote lecture: The insulin-resistant brain – Martin Heni (DE)
                       Chair: Åke Sjöholm

12:20-13:20 Lunch symposium – Eli Lilly

13:20-14:05 Keynote lecture: Advances in oligogenic diabetes – Amélie Bonnefond (FR)
                        Chair: Daniel Espes (SE)

14:05-14:50 Keynote lecture: Advances in diabetic nephropathy – Peter Rossing (DK) – Online presentation.
                        Chair: Gustaf Chrostoffersson (SE)

14:50-15:20 SSSD Young Investigator Award – Mikkel Thor Olsen
                        Chair: Elisabeth Qvigstad (NO)

15:20-16:05 Keynote lecture: Glucokinase as a therapeutic target in diabetes – Elaine Chow (HK)
                        Chair: Åke Sjöholm (SE)

16:05-16:50 Keynote lecture: Diabetes technology: Sensors and pumps – Jarl Hellman (SE)
                       Chair: Signe Schmidt (DK)

16:50-17:10 Coffee and visit to exhibition

17:10-17:55 Keynote lecture: Survival of transplanted allogeneic β-cells with no immunosuppression – Per-Ola Carlsson (SE)
                      Chair: Gustaf Christoffersson (SE)

17:55-18:55 Abstract session #3A:

Ephemeral diabetes after Covid-19 vaccination – Sarah-Ålivia Mänd
                       Åke Sjöholm

Targeted serum proteomics of longitudinal samples from newly diagnosed youth with type 1 diabetes affirms markers of disease – Robert Moulder
                     M.Karoliina Hirvonen, Tommi Välikangas, Tomi Suomi, Lut Overbergh, Mark Peakman, Søren Brunak, Chantal Mathieu, Mikael Knip, Laura L Elo,                                        Riitta Lahesmaa

THE INFLUENCE OF PARENTAL ROLE MODELING AND GENDER ON PHYSICAL ACTIVITY PATTERNS IN CHILDREN WITH TYPE 1 DIABETES –                                            Hilla Hannola,  Tytti Pokka, Maisa Niemelä, Marika Paalanne, Raija Korpelainen, Anna-Maiju Leinonen, Päivi Tossavainen

Treatment with GAD in LADA – follow-up of a clinical trial – Valdemar Grill
                      Indusmita Routray, Chandima Balasuyria, Rosaura Casas, Anneli Björklund, Ingrid Hals

Chair: Robin Lindsay (SE)

17:55-18:55  Abstract session #3B:

Electrical activity and Ca2+ dependent plasticity in human pancreatic β-cells – Santiago Echeverry
                        Per-Eric Lund, Symar Hamdan, Jan Saras, Sebastian Barg

Epigenetic Impact of GLP-1 Receptor Agonists on Pancreatic β-Cells – Yuke Wu
                        Yanying Li, Xuan Wang

Ex vivo and in vivo experimental investigation of miR-148a-3p as a novel therapy for insulin secretion and type 2 diabetes – Lena Eliasson
                        Elaine Cowan, Akira Asai, Jones Ofori, Jonathan Esguerra, Charlotte Ling, Anna Wendt, Mototsugu Nagao

INHIBITION OF VOLTAGE-DEPENDENT ANION CHANNEL 1 OLIGOMERIZATION AS A TREATMENT OPTION FOR TYPE 1 DIABETES – Ruchi Jain
                       Christian C. Lachaud, Cecillia Frej, Cornelia Nilsson, Benoit R. Gauthier, Claes B. Wollheim

Mitochondria – insulin granule crosstalk controls the early stages of granule maturation – Kousik Mandal
                        Styliani Panagiotou, Sofia Amini, Kia Wee Tan, Samuel B. Stephens, Olof Idevall-Hagren

                      Chair: Ragnar Grímur Bjarnason (IS)

19:30 –         Congress dinner at Elite Grand Hotel

  Saturday 23 May

 

08:00-08:30 General assembly of the SSSD

08:30-09:15 Keynote lecture: Mechanisms of exocytosis in pancreatic islet cells – Patrik Rorsman (UK)
                        Chair: Gustaf Christoffersson (SE)

09:15-10:00 Keynote lecture: Mechanistic insights and approaches for β-cell regeneration – Olov Andersson (SE)
                       Chair: Åke Sjöholm (SE)

10:00-10:45 Keynote lecture: Incretin therapy of obesity and diabetes – Jens J. Holst (DK)
                       Chair: Åke Sjöholm (SE)

10:45-11:05 Coffee and visit to exhibition

11:05-11:50 Keynote lecture: Is type 1 diabetes an inflammatory pancreatic disease with its main clinical symptoms due to the loss of the β-cells? – Olle Korsgren (SE)
                       Chair: Gustaf Christoffersson (SE)

11:55-12:55 Abstract session #4A:

                       Adenosine deaminase and adenosine monophosphate deaminase 2 delays onset of Type 1 diabetes in mice – Ronja  Andersson
                       Kailash Singh, Tongjian Zhao, Anongnad Ngamjariyawat, Kina Adjieva, Mudhir Shekha, Averina Octaxena Aslani, Martin Blixt, Zhengkang Luo,                                                     Stellan Sandler, Nils Welsh

                      Impact of cold ischemia on pancreatic islet function and beta-cell gene expression: studies with brain-dead donor biopsies and human isolated islets –                                                  Teresa Pereira, Joel Gelin, Casian Aioanei, Daniel Espes

                       Recapitulating islet vascular remodelling in mouse models of long-standing type 1 diabetes – Casian Aioanei
                      Teresa Pereira, Daniel Espes

                      The Immunomodulatory Role of Catestatin in Pancreatic Islets: Neuroimmune Interactions and Implications for Autoimmune Diabetes –                                                                        Dali Epremidze, Joanna Whittaker, Lucas Hultgren, Simon Ekström, Helena Danielson, Sushil K. Mahata, Elke M. Muntjewerff, Gustaf Christoffersson

                        β cell-targeted mesencephalic astrocyte-derived neurotrophic factor gene therapy reverses β cell stress and  diabetes in mice – Huini Li
                       Julia Kiva, Marika Itkonen, Liisa Pilv, Maria Lindahl

                       Chair: Gudrun Höskuldsdóttir (IS)

11:55-12:55 Abstract session #4B:

                      Excess risk of cardiovascular disease and mortality following lower-extremity amputation in type 2 diabetes – Karin Bergqvist
                      Henrik Imberg, Sara Hallström, Jens Michelsen, Hanna Liljebäck, Stefan Franzén, Anna Norhammar, Annika Rosengren, Marcus Lind

                      Family planning and pregnancy in women with type 2 diabetes – a qualitative prequel to a digitally supported lifestyle intervention (ReproDiaT2D). –                                                 Jesini Selvarasa Anurathan, Sandra Dis Steintorsdottir, Astrid Melteig Stalheim, Line Wisting, Cecilie Varsi, Anne-Marie Aas, Elisabeth Qvigstad

                       Health and lifestyle habits in dog owners in Sweden – Klara Smedberg
                      Erika Roman, Anna Bergh, Sören Spörndly-Nees, Jan W. Eriksson, Lena V. Kallings, Josefin Söder

                      Whole-body magnetic resonance imaging reveals sex-specific anatomical signatures of type 2 diabetes risk in the UK Biobank – Rama Guggilla
                      Lars Lind, Susanna Larsson, Robin Strand, Håkan Ahlström, Xiaomei Chen, Yasemin Utkueri, Johan Öfverstedt, Joel Kullberg

                     Chair: Robin Lindsay (SE)

13:00-        Closning remarks and departure lunch – Chair of local organizing committee: Åke Sjöholm (SE)