Preliminary program, to be continually updated.

Thursday 21 May

11:30-13:00 Registration

12:00-13:00 Lunch symposium – TBN

13:00-13:10 Opening and welcome remarks – Åke Sjöholm (SE) and Anders Kottorp, Vice Chancellor of the University of Gävle (SE)

13:10-13:55 Keynote lecture: Factors affecting the progression rate from seroconversion to autoantibody positivity to clinical type 1 diabetes – Mikael Knip (FIN)
                      Chair: Daniel Espes (SE)

13:55-14:15 Coffee and visit to exhibition

14:15-15:00 Barndiabetesfondens Johnny Ludvigsson Nordic Prize: Early signs of type 1 diabetes – Riitta Lahesmaa (FIN)
                      Chair: Johnny Ludvigsson (SE)

15:00-15:30 Barndiabetesfondens Young Swedish Investigator Prize:
                       Investigations of local immune regulatory mechanisms in type 1 diabetes – Gustaf Christoffersson (SE)

15:30-16:30 Abstract session #1A:

                     Cord Blood Iron Status has Age-specific Role in Future Type 1 Diabetes Diagnosis – Debojyoti Das
                       Johnny Ludvigsson

                     Detection of islet autoantibodies in breast milk of mothers with type 1 diabetes – Anna-Maria Lampousi
                       Marion E.G. Brunck, Johnny Ludvigsson

                     Epigenetic–proteomic network crosstalk at birth across HLA risk groups in type 1 diabetes – Shamila Darvish Alipoor Astaneh
                       Angelica Ahrens, Julia Åkesson, Johnny Ludvigsson

                    Integrated analysis of clinical course and proteomics data in DIAGNODE-2 patients – Debojyoti Das
                      Indusmita Routray, Johnny Ludvigsson

                     Stem cell derived islet organoids attract T cells, resulting in MHC matched organoid destruction by type 1 diabetic patient T cells. – Robin Lindsay
                       Xenia Podlipensky, Kina Adjieva, Marleen Bootsma, Svitlana Vasylovska, Anja Ivis, Carl Andersson, Gustaf Chistoffersson, Joey Lau

15:30-16:30 Abstract session #1B:
                       Regulation of insulin secretion by Ras signalling in pancreatic β-cells – Yunjian Xu
                         Moa Södergren, Santiago Echeverry, Per-Eric Lund, Oleg Dyachok, Olof Idevall, Sebastian Barg, Anders Tengholm

                     Novel METTL3/14 methyltransferase activators for protecting pancreatic beta- cells in diabetes mellitus – Julia Kiva
                       Huini Li, Maria Lindahl

                     Increasing the enteroendocrine cells by stimulating secretory progenitors with a Vcp-mediated autophagy activator – Lorenzo Buttò
                       Lianhe Chu, Jiarui Mi, Stefan Ebmeyer, Jeremie Charbord, Agnese Kocere, Anna Johansson, Olov Andersson

                    The Welander TIA1 mutation dedifferentiates human insulin-producing cells by upregulating MYC, an effect prevented by the GLP-1R agonist                                        liraglutide – Tongjian Zhao
                      Jing Cen, Xuan Wang, Mingyu Yang, Joey Lau, Anders Tengholm, Åke Sjöholm, Nils Welsh

                    Characterization of glucose tolerance, islet cell function, and insulin sensitivity in patients with Welander distal myopathy – Åke Sjöholm
                      Zhanchun Li, Joey Lau, Sarah-Ålivia Mänd, Niklas Dahl, Per-Ola Carlsson, Nils Welsh

                     Chair: Daniel Espes (SE)

16:30-17:15 Keynote lecture: GRK-biased adrenergic agonists for the treatment of type 2 diabetes and obesity – Tore Bengtsson (SE)
                      Chair: Åke Sjöholm (SE)

17:15-18:15  Novo Nordisk Foundation Nordic Diabetes Prize – TBN
                       Chair: TBN

18:15-18:30 Short break

 18:30-19:30 Role of VEGF-B signaling in diabetic complications: focusing on fatty liver disease and diabetic stroke – Ulf Eriksson (SE)
                       Chair: Åke Sjöholm

19:30-           Welcome Reception

Friday 22 May

08:00-08:45 Knud Lundbæk Award – TBN
                          Chair: TBN

08:45-09:30 Keynote lecture: Lipodystrophies and the road to diabetes – Fredrik Karpe (UK)
                        Chair: TBN

09:30-10:30 Abstract session #2A:

                         Anti-CD3 monoclonal antibody modulates gamma-aminobutyric acid (GABA)ergic activity in T cells from healthy and type 1 diabetes individuals –                             Zhe Jin
                          Bryndis Birnir, Jarl Hellman

                        Associations between type 1 diabetes and BMI at 1.5 and 4 years of age – Elsa Palmkvist
                         Marlena Maziarz, Charlotte Nylander, Ola Hansson, Annelie Carlsson

                       Characterization of the human virome in a childhood Type 1 diabetes cohort; focus on circoviruses – Amanj Bajalan
                         Edmundo Grisard, Claudia Beck Eichler Jonsson, Tobias Allander, Björn Andersson, Johnny Ludvigsson

                        Early life islet autoimmunity in type 1 diabetes among children frequently followed in a prospective birth cohort study – Nelli Rönkä
                         Tiia Honkanen, Anni Kyrönniemi, Toni Valtanen, Johanna Lempainen, Heikki Hyöty, Jorma Toppari, Jaakko Koskenniemi, Mikael Knip, Taina Härkönen,                                           Tytti Pokka, Riitta Veijola

                        Gene Expression Signatures Associated with Disease Progression in Individuals with Newly Diagnosed Type 1 Diabetes: Insights from the                                                INNODIA Study – Tomi Suomi
                         Inna Starskaia, Omid Rasool, Ubaid Ullah Kalim, Sylvaine Bruggraber, Loredana Marcovecchio, Emile Hendricks, Lut Overbergh, Mark Peakman, Timothy Tree,                           Søren Brunak, Anke M Schulte, Chantal Mathieu, Mikael Knip, Riitta Lahesmaa, Laura L Elo

09:30-10:30 Abstract session #2B:

                      Effect of impaired glycogenolysis and glycogen excess on exercise-mediated glucose metabolism in skeletal muscle: Insights from novel mouse                                    models – Dipsikha Biswas
                        Marianne Agerholm, Joachim Nielsen, Mohd. Syed Ahanger, Elton Zeqiraj, Kei Sakamoto

                      Exploring predictors for long-term clinical benefit after gastric bypass and sleeve gastrectomy in type 2 diabetes: A Machine Learning Approach –                                Gudrun Höskuldsdóttir
                        Ala Mejaddam, Moa Lugner, Hanne Carlsen, Araz Rawshani, Ingrid Larsson, Johan Ottosson, Katarina Eeg-Olofsson, Kerstin Landin-Wilhelmsen, Björn Eliasson

                     Extracellular Vesicle associated Glycosylated Sphingolipid Alterations in Type 2 Diabetes Impair Adipocyte Glucose Metabolism – Daan Paget
                     Jutta Jalkanen, Svetlana Michurina, Kirstin MacGregor, Antonio Checa, Niklas Mejhert, Taras Sych, Erdinc Sezgin, Harriet Wallberg-Henriksson,                                   Juleen Zierath, Anna Krook

                     Therapeutic Targeting of the ANGPT2/TIE2 Signaling Axis Improves Diabetic Nephropathy in the BTBR OB/OB Mouse –
                     Amanda M. Marks-Hultström
                       Marie Jeansson

                     Tuning GRK2-biased β₂ signaling: next-generation muscle-targeted modulators with enhanced metabolic and anabolic profiles – Nodi Dehvari
                       Anastasia Kalinovich, Carina Halleskog, Hamza Bukhari, Sofia Karlström, Tore Bengtsson

                      Chair: TBN

10:30-10:50 Coffee and visit to exhibition

10:50-11:35 Keynote lecture: Exercise timing and circadian regulation of metabolism in type 2 diabetes – Harriet Wallberg (SE)
                        Chair: TBN

11:35-12:20 Keynote lecture: The insulin-resistant brain – Martin Heni (DE)
                       Chair: Åke Sjöholm

12:20-13:20 Lunch symposium – TBN

13:20-14:05 Keynote lecture: Advances in oligogenic diabetes – Amélie Bonnefond (FR)
                        Chair: TBN

14:05-14:50 Keynote lecture: Advances in diabetic nephropathy – Peter Rossing (DK) – Online presentation.
                        Chair: TBN

14:50-15:20 SSSD Young Investigator Award – TBN
                        Chair: TBN

15:20-16:05 Keynote lecture: Glucokinase as a therapeutic target in diabetes – Elaine Chow (HK)
                        Chair: Åke Sjöholm (SE)

16:05-16:50 Keynote lecture: Diabetes technology: Sensors and pumps – Jarl Hellman (SE)
                       Chair: TBN

16:50-17:10 Coffee and visit to exhibition

17:10-17:55 Keynote lecture: Survival of transplanted allogeneic β-cells with no immunosuppression – Per-Ola Carlsson (SE)
                      Chair: TBN

17:55-18:55 Abstract session #3A:

                     Ephemeral diabetes after Covid-19 vaccination – Sarah-Ålivia Mänd
                       Åke Sjöholm

                    Pancreatic islets in mice and humans: unravelling mechanisms driving beta cell proliferation under metabolic stress – Leonie Reible
                      Teresa Pereira, Daniel Espes

                   Targeted serum proteomics of longitudinal samples from newly diagnosed youth with type 1 diabetes affirms markers of disease – Robert Moulder
                     M.Karoliina Hirvonen, Tommi Välikangas, Tomi Suomi, Lut Overbergh, Mark Peakman, Søren Brunak, Chantal Mathieu, Mikael Knip, Laura L Elo,                                                     Riitta Lahesmaa

                   THE INFLUENCE OF PARENTAL ROLE MODELING AND GENDER ON PHYSICAL ACTIVITY PATTERNS IN CHILDREN WITH TYPE 1 DIABETES –                                     Hilla Hannola
                    Tytti Pokka, Maisa Niemelä, Marika Paalanne, Raija Korpelainen, Anna-Maiju Leinonen, Päivi Tossavainen

                   Treatment with GAD in LADA – follow-up of a clinical trial – Valdemar Grill
                    Indusmita Routray, Chandima Balasuyria, Rosaura Casas, Anneli Björklund, Ingrid Hals

17:55-18:55 Abstract session #3B:

                   Electrical activity and Ca2+ dependent plasticity in human pancreatic β-cells – Santiago Echeverry
                    Per-Eric Lund, Symar Hamdan, Jan Saras, Sebastian Barg

                  Epigenetic Impact of GLP-1 Receptor Agonists on Pancreatic β-Cells – Yuke Wu
                  Yanying Li, Xuan Wang

                  Ex vivo and in vivo experimental investigation of miR-148a-3p as a novel therapy for insulin secretion and type 2 diabetes – Lena Eliasson
                   Elaine Cowan, Akira Asai, Jones Ofori, Jonathan Esguerra, Charlotte Ling, Anna Wendt, Mototsugu Nagao

                  Impact of cold ischemia on pancreatic islet function and beta-cell gene expression: studies with brain-dead donor biopsies and human isolated islets –                      Teresa Pereira
                    Joel Gelin, Casian Aioanei, Daniel Espes

                  Mitochondria – insulin granule crosstalk controls the early stages of granule maturation – Kousik Mandal
                   Styliani Panagiotou, Sofia Amini, Kia Wee Tan, Samuel B. Stephens, Olof Idevall-Hagren

                   Chair: TBN

19:30 –    Congress dinner

Saturday 23 May

08:00-08:30 General assembly of the SSSD

08:30-09:15 Keynote lecture: Mechanisms of exocytosis in pancreatic islet cells – Patrik Rorsman (UK)
                        Chair: TBN

09:15-10:00 Keynote lecture: Mechanistic insights and approaches for β-cell regeneration – Olov Andersson (SE)
                          Chair: Åke Sjöholm (SE)

10:00-10:45 Keynote lecture: Incretin therapy of obesity and diabetes – Jens J. Holst (DK)
                       Chair: Åke Sjöholm (SE)

10:45-11:05 Coffee and visit to exhibition

11:05-11:50 Keynote lecture: Is type 1 diabetes an inflammatory pancreatic disease with its main clinical symptoms due to the loss of the β-cells? –                                                         Olle Korsgren (SE)
                       Chair: TBN

11:55-12:55 Abstract session #4A:

                     Adenosine deaminase and adenosine monophosphate deaminase 2 delays onset of Type 1 diabetes in mice – Ronja  Andersson
                       Kailash Singh, Tongjian Zhao, Anongnad Ngamjariyawat, Kina Adjieva, Mudhir Shekha, Averina Octaxena Aslani, Martin Blixt, Zhengkang Luo,                                                           Stellan Sandler, Nils Welsh

                      INHIBITION OF VOLTAGE-DEPENDENT ANION CHANNEL 1 OLIGOMERIZATION AS A TREATMENT OPTION FOR TYPE 1 DIABETES – Ruchi Jain
                        Christian C. Lachaud, Cecillia Frej, Cornelia Nilsson, Benoit R. Gauthier, Claes B. Wollheim

                      Recapitulating islet vascular remodelling in mouse models of long-standing type 1 diabetes – Casian Aioanei
                        Teresa Pereira, Daniel Espes

                      The Immunomodulatory Role of Catestatin in Pancreatic Islets: Neuroimmune Interactions and Implications for Autoimmune Diabetes –                                                  Dali Epremidze
                        Joanna Whittaker, Lucas Hultgren, Simon Ekström, Helena Danielson, Sushil K. Mahata, Elke M. Muntjewerff, Gustaf Christoffersson

                     β cell-targeted mesencephalic astrocyte-derived neurotrophic factor gene therapy reverses β cell stress and  diabetes in mice – Huini Li
                       Julia Kiva, Marika Itkonen, Liisa Pilv, Maria Lindahl

11:55-12:55 Abstract session #4B:

                     Excess risk of cardiovascular disease and mortality following lower-extremity amputation in type 2 diabetes – Karin Bergqvist
                      Henrik Imberg, Sara Hallström, Jens Michelsen, Hanna Liljebäck, Stefan Franzén, Anna Norhammar, Annika Rosengren, Marcus Lind

                     Family planning and pregnancy in women with type 2 diabetes – a qualitative prequel to a digitally supported lifestyle intervention (ReproDiaT2D). –                         Jesini Selvarasa Anurathan
                      Sandra Dis Steintorsdottir, Astrid Melteig Stalheim, Line Wisting, Cecilie Varsi, Anne-Marie Aas, Elisabeth Qvigstad

                     Health and lifestyle habits in dog owners in Sweden – Klara Smedberg
                      Erika Roman, Anna Bergh, Sören Spörndly-Nees, Jan W. Eriksson, Lena V. Kallings, Josefin Söder

                    Whole-body magnetic resonance imaging reveals sex-specific anatomical signatures of type 2 diabetes risk in the UK Biobank – Rama Guggilla
                      Lars Lind, Susanna Larsson, Robin Strand, Håkan Ahlström, Xiaomei Chen, Yasemin Utkueri, Johan Öfverstedt, Joel Kullberg

                     Chair: TBN

13:00-       Closning remarks and departure lunch – Chair of local organizing committee: Åke Sjöholm (SE)